Physician’s Weekly podcast – The PSA Test Controversy

In a lively discussion, E. David Crawford, MD (University of Colorado), explains the controversy around prostate-specific antigen (PSA) test screening. The National Cancer Institute describes the PSA controversy as follows: “Using the PSA test to screen men for prostate cancer is controversial because it is not yet known for certain whether this test actually saves […]

Valley News: Are we getting it wrong on prostate cancer screening?

James Heffernan, an emeritus professor of English at Dartmouth College, speaks of his experience with prostate cancer and makes a case for early detection through prostate cancer biomarkers.

Living Your Healthiest Life By Understanding Your Prostate Cancer Risk

Learn more about how routine PSA testing can be a critical part of living your healthiest life!

The PSA Test Controversy, Doctor Vs Insurer on Settlements

In a lively recorded discussion, E. David Crawford MD explains the controversy around prostate-specific antigen (PSA) test screening. Listen to the full conversation on this episode of the Physician’s Weekly podcast.

9News: Health officials urge people to get preventative screenings for prostate cancer

Dr. E. David Crawford, MD, on a featured story for CBS 9 News in Denver, Colorado regarding early PSA screening.

Prostate-specific antigen 1.5-4.0 ng/mL: a diagnostic challenge and danger zone

Both Caucasian and African American men with baseline PSA values between 1.5 and 4.0 ng/mL are at increased risk for future prostate cancer compared with those who have an initial PSA value below the 1.5 ng/mL threshold. Based on a growing body of literature and this analysis, it is recommended that a first PSA test threshold of 1.5 ng/mL and above, or somewhere between 1.5 and 4.0 ng/mL, represent the Early-Warning PSA Zone (EWP Zone). 

96% Negative Predictive Value for High-grade Cancer

This study shows that, when compared to other risk factors, detection of DNA-methylation in histopathologically negative biopsies was the most significant and important predictor of high-grade cancer, resulting in a negative predictive value of 96%.   

Pre-diagnosis urine exosomal RNA (ExoDx EPI score) is associated with post-prostatectomy pathology outcome

ExoDx Prostate IntelliScore (EPI) is a non-invasive urine exosome RNA-based test for risk assessment of high-grade prostate cancer. We evaluated the association of pre-biopsy test results with post-radical prostatectomy (RP) outcomes to understand the potential utility of EPI to inform invasive treatment vs active surveillance (AS) decisions.

Beyond PSA: The Role of Prostate Health Index (phi)

Literature data showed that phi had good diagnostic performance to identify clinically significant (cs) PCa, suggesting that it could be a useful tool for personalized treatment decision-making. In this review, phi potentialities, limitations, and comparisons with other blood- and urinary-based tests were explored.

A Multi-Institutional Prospective Trial Confirms Noninvasive Blood Test Maintains Predictive Value in African American Men

The 4Kscore test accurately detects aggressive prostate cancer and reduces unnecessary biopsies yet, its performance in African American men has been unknown. We assessed test performance in a cohort of men with a large African American representation and confirmed that the 4Kscore test accurately predicts aggressive prostate cancer for biopsy decision making in African American […]