Interpretation: This section describes the overall risk result of your Decipher test. Generally, the lower the Decipher Score (0 being lowest risk to 1 being highest risk) the lower the risk of metastatic spread. This score, as well as your risk percent likelihood (described below) may help your doctor decide to initiate treatment after surgery to reduce the risk of metastases such as hormone deprivation therapy, and/or external beam radiation.
5 Year Metastasis This represents your overall risk of having prostate cancer that has spread to other areas, most commonly bone. In this example, 1.6% likelihood means that, if the patient underwent radical prostatectomy, there would be a 1.6% chance the patient may develop metastasis within 5 years. The higher the percentage, the greater the risk.
10 Year Prostate Cancer Specific Mortality:
This represents your overall risk of prostate cancer specific death after 10 years based on the genomic characteristics of your prostate cancer. In this example 2.5% likelihood means that, if the patient underwent a radical prostatectomy, there would be a 2.5% chance the patient may die from prostate cancer at 10 years. The higher the percentage, the greater the risk. This score does not reflect your overall risk of dying of other causes.
This section is a visual representation for the overall result of the risk classification for the highest grade cancer that was sampled after your prostate was removed.
Clinical Details: This area describes the clinical details associated with your prostate cancer. This information is gathered from your pathology report and is not NOT used to generate your Decipher result.
SM+ (positive surgical margins), indicates that the the prostate cancer is at a margin of removal. This usually means the cancer has penetrated through the prostate capsule. Another cause is that during removal the surgeon will “cut” into the cancer while removing the gland.
EPE (extra prostatic extension), means that there was evidence that cancer had gone outside the capsule of the prostate.Depending on the extent of the removal, there may be a positive margin, but not always.
SVI (seminal vesicle invasion) means that the seminal vesicles, which were removed along with your prostate, had evidence of prostate cancer present, suggesting that the cancer had began to spread locally outside the prostate. The seminal vesicles are an escape route for more distant spread of the cancer.
LNI (lymph node invasion) means that there was evidence that prostate cancer had invaded one or more lymph nodes (glands where the immune system resides).
BCR (biochemical recurrence) means that after your surgery, your PSA is above acceptable levels (usually, greater than or equal to .2 ng/dl).
Tertiary Gleason 5 means that there was evidence of a third Gleason score or small area of Gleason 5 present on your pathology result.
Confidence Intervals: For a 95% confidence interval, it means that if the same population is sampled many times the test results would fall within the confidence intervals 95% of the time.
This section describes how the Decipher test works. Essentially, a panel of molecular biomarkers specific to prostate cancer progression and metastasis, represented by multiple biological pathways, are examined from the tumor tissue to determine your individual Decipher Score.
Intended Use: This section describes how the Decipher Test was intended to be used as a decision making tool between a patient and their physician, and the type of patient who would benefit most from the test.