What do my Ambry Score Results Mean?
The Ambry Score is a genetic PCM that can be added on as a supplementary PCM to other tests, such as the ProstateNext test.
The Ambry Score is known as a polygenic risk score (PRS), which means it can evaluate the genetic variants a man inherited at birth to determine that individual’s risk of having developed or risk of eventually developing prostate cancer.
The Ambry Score evaluates an individual’s risk by examining the patient’s age at testing, their ethnicity, and 72 single nucleotide polymorphisms (SNPs). A SNP is an error that exists in one’s genetic code, or DNA. These SNPs are unique to each individual, and are usually inherited from ones parents. Through researching populations of men, these 72 SNPs have been identified as being associated with prostate cancer risk. At the current time, the test is only available for men of Northern European descent.
The results of the Ambry Score, in combination with other tests, such as ProstateNext, can help your healthcare provider determine your risk of having developed or eventually developing prostate cancer as a result of these SNPs. These results, along with other personal risk factors and PCMs, can be used as a tool by your healthcare provider to develop a customized monitoring or treatment plan specific to your needs.
Patient Sample Test
This page contains a series of sample reports, scroll through to view the respective results for each risk category.
Unaffected Male at Average Risk
Below is an example of an Ambry Score where the patient was presented without a diagnosis of prostate cancer, but had a family or personal history that put him at higher risk for hereditable cancers. The results of this test indicates that this individual is at average risk of developing cancer over his lifetime. This individual should speak with their healthcare provider about developing an appropriate screening plan.
Unaffected Male at Increased Risk
Below is an example of an Ambry Score where the patient was presented without a diagnosis of prostate cancer, but had a family or personal history that put him at higher risk for hereditable cancers. The results of this test indicates that this individual is at increased risk of developing cancer over his lifetime. This individual should should speak with their healthcare provider about developing an appropriate, more rigorous screening plan. 
Affected Male at Average Risk
Below is an example of an Ambry Score where the patient was presented with a diagnosis of prostate cancer, and had a family or personal history that put him at higher risk for hereditable cancers. The results of this test indicates that this individual’s polygenic risk score (PRS) is below the population baseline level of 1.0. These results suggest that the patient’s cancer likely did not occur as a result of an error related to the 72 SNPs associated with prostate cancer development.
Use of this Ambry Score risk estimate for the patient’s medical management and planning should be left to the discretion of the healthcare provider, and interpreted in the context of patient age, clinical history, and family history.
Affected Male at Increased Risk
Below is an example of an Ambry Score where the patient was presented with a diagnosis of prostate cancer, and had a family or personal history that put him at higher risk for hereditable cancers. The results of this test indicates that this individual’s polygenic risk score (PRS) is above the population baseline level of 1.0. These results suggest that the patient’s cancer may have occurred as a result of an error related to the 72 SNPs, as well as other factors, associated with prostate cancer development.
Use of this Ambry Score risk estimate for the patient’s medical management and planning should be left to the discretion of the healthcare provider, and interpreted in the context of patient age, clinical history, and family history.
