Prompt PGS Genetic Test

This genetic test helps determine a man’s risk of prostate cancer.

What is the PromptPGS genetic test for prostate cancer?

NOTE: The Prompt PGS test is currently not available.

Prompt Prostate Genetic Score (PGS) is a genetic test that can help a man determine his individual risk for prostate cancer. Prompt PGS uses a cheek swab to create a patient’s genetic profile, then combines that with the man’s family history and compares it to thousands of men with prostate cancer. While a valuable genetic test, Prompt PGS is currently only accurate for use in white and Hispanic men.

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PromptPGS Video

Learn more about the PromptPGS genetic test, which assesses a man’s lifetime risk of developing prostate cancer.

Understanding Your PromptPGS Test Results

Prompt PGS is  genetic test that can be effective in helping a man determine his hereditary risk for prostate cancer. See a sample PromptPGS results report and learn more about how to interpret the report. Please note that you should always review test results with your healthcare provider or a genetic counselor first.

Prompt PGS FAQs

Below is an initial list of frequently asked questions about the Prompt PGS test. You can also submit your question.

1. Why should men consider additional testing beyond the PSA test?

The PSA test cannot differentiate between prostate cancer and non-cancerous (benign) conditions, such as benign prostatic hyperplasia (BPH). Men who receive a PSA level above 1.5 ng/ML should discuss additional biomarker testing with their healthcare providers prior to considering a prostate biopsy.

2. What are prostate cancer biomarkers (PCMs)?

Prostate cancer biomarkers (PCMs) are molecules found in blood, tissue, or body fluids. PCMs are revolutionary new, non-invasive diagnostic tests that may help your healthcare provider decide if your prostate cancer is in fact low risk, if something more aggressive may be lurking in your prostate, or if there are hot spots in the prostate that may need to be re-evaluated upon biopsy. PCMs also can help you and your healthcare provider determine the most appropriate treatment for your cancer.

3. What prostate cancer biomarker test is right for me?

There are many factors that will make one prostate cancer marker test better suited for individual cases. Many times, individuals who have never had a biopsy or had low to intermediate grade prostate cancer (Gleason 3+3=6 or 3+4=7) diagnosed on a biopsy are well suited for blood or urine prostate cancer markers, whereas individuals who have persistently negative biopsies or a biopsy of intermediate to high grade cancer may benefit from tissue prostate cancer markers. Use this interactive questionnaire to see what tests may be right for you.  Once you’ve completed the questionnaire, discuss the results with your healthcare provider. Also be sure to check out our Patient Journey section that may help you decide which test is right for you.

4. Are there any prostate cancer biomarker (PCM) tests that could help me decide if I need to have a prostate biopsy?

Although there are many factors that contribute to your healthcare provider’s decision to conduct a prostate biopsy, there are several urinary and blood based PCMs that may help guide you and your physician through the decision of conducting a prostate biopsy. These include:

Genetic tests also may be worth considering if you have a family history of prostate cancer, breast cancer, ovarian cancer or colorectal cancer. These genetic tests are recommended for men who are determined through genetic counseling to be at potential risk for hereditary cancer:

5. Who should consider a Prompt PGS genetic test?

The Prompt PGS genetic test could provide insights for any white or Hispanic man who wants to understand his relative lifetime risk of developing prostate cancer. Men with any of the following may also consider the test:

  • want to know when or how often to screen
  • have a family member or blood relative with prostate cancer
  • are unaware of their prostate cancer family history
  • have fluctuating or indeterminate PSA levels
  • have a negative prostate biopsy
6. What does the Prompt PGS genetic test measure?

The Prompt PGS genetic test is a next-generation sequencing germline genetic DNA test performed on a patient’s cheek swab. Test results for Prompt PGS are presented as a personalized genetic score for a patient’s risk of developing prostate cancer. The results are presented as follows: below average risk, average risk and above average risk. See a sample Prompt PGS test report and learn more about interpreting this Report.