ProstateNext Genetic Test

This genetic test analyzes 14 genes, including the BRCA1 and BRCA2 genes, associated with hereditary cancers.

What is the ProstateNext genetic test?

ProstateNext® is a genetic test that analyzes 14 genes associated with hereditary prostate cancer.

ProstateNext, conducted with a blood or saliva sample, can help men and their healthcare provider:

  • Determine when to start prostate cancer screening tests and how often the tests should be repeated
  • Identify at-risk family members
  • Suggest measures to reduce the patient’s individual risk of developing prostate cancer
  • Tailor treatment to the patient if he develops prostate cancer

Of the 14 genes reviewed in the ProstateNext test are BRCA1 and BRCA2 (known as breast cancer predisposition genes). These genes, when mutated, have been shown to be associated with a 15% lifetime risk of developing prostate cancer, which is significantly higher than the average risk

ProstateNext Video

Learn more about the ProstateNext test, which assesses a patient’s risk for hereditary prostate cancer.

Understanding Your ProstateNext Results

The ProstateNext test is a genetic test that can be effective in determining a person’s risk of developing hereditary prostate cancer. See a sample ProstateNext result report and learn more about how to interpret these results. Please note that all ProstateNext test results should always be discussed with a healthcare provider or genetic counselor first.

ProstateNext FAQs

Below is an initial list of frequently asked questions about the ProstateNext test.

Are there any prostate cancer biomarker (PCM) tests that could help me decide if I need to have a prostate biopsy?

Although there are many factors that contribute to your healthcare provider’s decision to conduct a prostate biopsy, there are several urinary and blood based PCMs that may help guide you and your physician through the decision of conducting a prostate biopsy. These include:

Genetic tests also may be worth considering if you have a family history of prostate cancer, breast cancer, ovarian cancer or colorectal cancer. These genetic tests are recommended for men who are determined through genetic counseling to be at potential risk for hereditary cancer:

How do I know if I'm a candidate for genetic testing?

If you answer “Yes” to any of the questions below, you may want to consider talking to your healthcare provider about hereditary cancer genetic testing.

  • Have you or your family members been diagnosed with:
    • cancer at a young age (younger than 50 years old)?
    • more than one cancer?
    • cancers you’ve been told are usually rare, such as ovarian or pancreatic cancer?
  • Do you have multiple people on the same side of your family who have had or have cancer?
  • Have any of your family members been found to have a cancer gene mutation?
What results can I expect from genetic tests?

Results from your genetic tests will fall into one of three categories:


  • A mutation related to an inherited cancer has been found in at least one of your tested genes.
  • A positive result confirms an increased risk for an inherited cancer. This information may be used to inform decisions you and your healthcare provider make about your medical care.
  • A positive result also indicates there may be up to a 50/50 random chance that each of your children, brothers, sisters, and parents has this same mutation. This means, that like you, they are at increased risk to develop the cancer linked to your mutation and should consider genetic testing.


  • No cancer-linked genetic mutations were found in any of your tested genes.
  • Since inherited disease risk(s) and management recommendations are based on personal and family history as well as genetics, you will want to discuss next steps with your healthcare provider.
  • Despite your negative result, genetic testing may be advisable for family members depending on their health history.

Variant of unknown significance

  • At least one genetic mutation was found, but it is unclear if this mutation causes an increased risk for an inherited cancer.
  • Your next steps should be determined by your personal and family history.
  • As more genes are researched and additional testing becomes available, your results may change over time. This means that your variant of unknown significance could become known. It’s impossible to predict when this might happen though.